Post-doctoral reseaecher

Institute of Bioorganic Chemistry Polish Academy of Sciences

Organisation/Company Institute of Bioorganic Chemistry Polish Academy of Sciences Department Department of Genome Engineering Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Country Poland Application Deadline 24 Jul :00 (Europe/Brussels) Type of Contract Temporary Job Status Full-time Hours Per Week 40 Is the job funded through the EU Research Framework Programme? Not funded by an EU programme Reference Number 13/2024/SN Is the Job related to staff position within a Research Infrastructure? No

KEY WORDS: microsatellite sequences, CAG repeats, DNA repair, neurodegenerative diseases, gene therapy

Research topic: Investigation of the mechanisms of short tandem repeats instability

Principal Investigator: Marta Olejniczak, PhD, professor of IBCH PAS

Research will be carried out within the 2021/43/B/NZ2/01615 OPUS 22 project, entitled "Searching for new therapeutic targets in polyglutamine diseases", funded by National Science Centre.

The aim of this project is to better understand the mechanisms of CAG repeat instability and to identify new therapeutic targets that can be used for safe and controlled repeat shortening. We plan to achieve these goals through the following tasks: (1) identification of genes and cellular processes involved in CAG repeat instability, (2) validation of the participation of selected genes / pathways in the repeat instability process, (3) analysis of factors affecting CAG repeat instability (genetic context and cell type) and (4) controlled shortening of CAG repeats in a Huntington's disease mouse model.

ICHB PAN is one of the leading research units in Poland and conducts research activities in the field of chemistry, molecular biology and biomedicine. The Institute provides access to technologically advanced research equipment. The research will be carried out in collaboration with a team from ETH Zurich.

I. Requirements for the candidate:

• A PhD degree in molecular biology, biochemistry, biotechnology, or related sciences*.
• Well-documented research output in the form of research papers published in recognizable research journals listed in the Web of Science database.
• Good knowledge of molecular biology techniques and experience in working with cell cultures.
• Experience in the application of genome editing techniques (CRISPR-Cas), methods of studying protein-nucleic acid interactions (chromatin immunoprecipitation), RNAi, WES, NGS and proteomic analyzes is welcome.
• Very good work organization and strong motivation for scientific work.
• Ability to work independently and cooperate in a team.
• Very good command of spoken and written English

The offer is addressed to experienced scientists with at least a doctoral degree, to carry out research in the field of molecular biology in the context of human diseases.

*In accordance with the requirements of the National Science Centre, only those candidates who received their PhD degree no earlier than 7 years prior to the date of employment within the research project, excluding parental or related leaves governed by the stipulations of the Labor Code, rehabilitation period associated with rehabilitation allowances or other rehabilitation benefits, are eligible for recruitment. In such cases, the aforementioned 7-year period shall be extended by additional 18 months for every descendant or adoptee. Female applicants may choose the way of justifying breaks in their research career, which is more favorable in a given case.

Pursuant to the regulations of the National Science Centre, the admitted person must additionally meet one of the following conditions: (I) obtained a doctoral degree in a subject other than the Institute of Bioorganic Chemistry of the Polish Academy of Sciences or (II) completed at least 10-month, continuous and documented postdoctoral fellowship in an entity other than ICHB PAN and in a country other than Poland..

Research Field Biological sciences » Biology Education Level PhD or equivalent

The gross salary allocated: approximately 8150 PLN/month.

II.Job Responsibilities:

1. Generation of genetic constructs and development of modified cell lines

2. Knock-down of selected genes with the use of RNA interference technology

3. Optimization and implementation of protocols for the analysis of DNA molecules and proteins

4. Regular presentation of the results at department seminars

5. Analysis of results and preparation of publication manuscripts.

III. Required documents:

1. Letter of application to the Director of IBCH PAS with a statement confirming that the Institute shall be the candidate's primary place of employment.

2. Scientific CV including list of publications, patents, previous positions and managed projects.

3. Cover letter featuring information on the candidate's scientific background, achievements and contact details to three referees.

4. Copy of PhD diploma.

IV. Applications should be submitted via the eRecruiter portal:

V. The submission deadline is July 24, 2024.

Eligibility criteria

VI. Selection of candidates:

Following preliminary verification, on the basis of the application documents, selected candidates will be invited for an interview, and based on the results of both stages of applicants evaluation, one candidate shall be appointed. The main criteria, taken into consideration during the selection of the candidates, will be: (i) research output in a form of published papers, (ii) experience necessary for the tasks planned within the framework of the project, (iii) former foreign fellowships and /or post-doctoral positions held.

VII. The recruitment procedure shall be concluded no later than on July 31, 2024.

VIII.Employment shall take place in compliance with the provisions of the Labor Code of Poland.

Selection process

The position is available for the period of 23 months. The gross salary allocated: approximately 8150 PLN/month.

Pursuant to the stipulations of the regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), further referred to as GDPR, we hereby inform that:

• The Institute of Bioorganic Chemistry, Polish Academy of Sciences, seated in Noskowskiego St. 12/14, Poznan; REGON , NIP is the administrator of the collected personal data (further referred to as the Institute).
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