Postdoctoral scientist

Mossakowski Medical Research Institute, Polish Academy of Sciences

Organisation/Company Mossakowski Medical Research Institute, Polish Academy of Sciences Department Department of Neurotoxicology Research Field Biological sciences » Other Researcher Profile Recognised Researcher (R2) Country Poland Application Deadline 15 Jul :59 (Europe/Warsaw) Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Oct 2024 Is the job funded through the EU Research Framework Programme? Not funded by an EU programme Reference Number ZNTK Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Project title: Role of GAB glutaminase in glioblastoma.

Department of Neurotoxicology, Mossakowski Medical Research Institute Polish Academy of Sciences is recruiting to the NCN OPUS 21 project entitled "Role of GAB glutaminase in glioblastoma" (2021/41/B/NZ5/01883).

The project:

A growing body of evidence suggests that GAB glutaminase acts as a tumor suppressor. Our previous studies clearly indicate that: i) glioblastoma (GBM), the most malignant glial tumor, lacks GAB; ii) transfection of GBM cells with a GAB sequence inhibits their survival, proliferation, migration, and sensitizes them to oxidative stress and temozolomide, a first-line chemotherapeutic agent for GBM.

The main objective of this project is to elucidate the molecular determinants of tumor-suppressive properties of GAB observed in GBM cells and examine the influence of GAB transfection on the phenotype of GBM cells in in vivo settings. The main hypothesis of this project, supported by preliminary results and data from the literature, is that transfection with a GAB sequence suppresses malignant phenotype of GBM cells by modulation of the transcriptome/miRNome and/or proteome of these cells. Results from this project will enrich the existing knowledge about the role of GAB in GBM cells.

Skills/Qualifications

1. PhD Degree (or equivalent) in bioinformatics, biology, biotechnology or related fields.

2. Experience in the analysis of multi-omics data

3. Scientific achievements documented by publications

4. Very good command of English and practice in scientific writing/presentation of scientific data in English

5. Communication skills, openness to new challenges, very good organization of laboratory work, creative and analytical thinking

6. Experience in experimental work in a molecular laboratory will be an additional advantage

Specific Requirements

The post-doc will be responsible for:

• analysis and interpretation of multi-omics data;
• present results at team meetings, seminars and conferences, and through scientific publications;
• supervise students engaged in the project;

Contract type:work agreement, full-time

Contract length:up to 18 months, start 01 October 2024

Salary: Gross salary (total employment cost) of 10000 PLN/month (total employment cost is the gross/gross amount including employer's expense, social and health insurances)

Requirements

Research Field Biological sciences » Other Education Level PhD or equivalent

Skills/Qualifications

1. PhD Degree (or equivalent) in bioinformatics, biology, biotechnology or related fields.

2. Experience in the analysis of multi-omics data

3. Scientific achievements documented by publications

4. Very good command of English and practice in scientific writing/presentation of scientific data in English

5. Communication skills, openness to new challenges, very good organization of laboratory work, creative and analytical thinking

6. Experience in experimental work in a molecular laboratory will be an additional advantage

Specific Requirements

The post-doc will be responsible for:

• analysis and interpretation of multi-omics data;
• present results at team meetings, seminars and conferences, and through scientific publications;
• supervise students engaged in the project;

Number of offers available 1 Company/Institute Mossakowski Medical Research Institute, Polish Academy of Sciences Country Poland City Warsaw Postal Code Street 5 Pawinskiego Street
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